Powder Oral Water Soluble Drugs - 1036 Words

About 70% of the new chemcial ntities are recognized as poorly water-soluble about 40% of commercially available immediate-release oral formulations are recognized as practically insoluble in water (Kawabata et al., 2001). Therefore, several potentially promising drug candidtates were rejected as pharmaceutical products due to ther poor solubilitty in GI fluid, poor dissolution in GI tract, low systemic absorption and thus poor oral bioavailability (therapeutically ineffective) (Hà ¶rter and Dressman, 2001). Therefore, enhancing the aqueous solubility and dissolution rate of poorly water-soluble drugs is one of the major challenges in pharmaceutical industry. The study was performed to improve the compactibility and the biopharmaceutical performance of xylitol by improving its physicomechanical properties to make it better suited for tableting using direct compression. To this end, antisolvent crystallization technique was employed in the presence of various additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol with a molecular weight (PVA22000) or 16000 (PVA16000) at varying concentrations (0.06%, 0.3%, 0.6% and 1.2%, w/v). The size and morphological changes induced by crystallization the in presence of the additives were studied. The dissolution performance of crystallized xylitols formulated with a model poorly water-soluble drug, i.e. indomethacin, in comparison to commercial xylitol were also evaluated. Materials and MethodsShow MoreRelatedEssential Drug Delivery Route Is No Doubt The Oral Route1408 Words   |  6 Pages The most essential drug delivery route is no doubt the oral route. It has advantages like convenience of administration and less developed cost. Drugs administered by oral route are solid oral dosage forms particularly tablets, the preferred class of product. Today drug delivery companies are concentrating on solid oral drug delivery systems that suggestion increased patient amenability and effect. Melt in mouth tablet (MMT)Read MoreTherapeutic Response Of A Drug Depends Upon The Dissolution Rate Of Water Insoluble Drugs Essay2676 Words   |  11 PagesTherapeutic response of a drug depends upon the bioavailability which in turn depends upon the solubility and dissolution rate of drug. A solubility problem is a major challenge for the pharmaceutical industry with developments of new pharmaceutical products. There are various techniques but liquisolid compact is a new and promising method that can change the dissolution rate of water insoluble drugs. According to the concept of liqui solid systems water-insoluble drugs dissolved in suitable non-volatileRead MoreVirtual Pharmaceutical: How It Works2390 Words   |  10 PagesOur company name: Virtual Pharmaceutical Drug name: VPL874C (Market name = Betatrix) Possible indications = migraine prophylaxis, hypertension, coronary heart disease Problem – want oral dosage form. - but has short half life (3-4hr) Solution – oral dosage form with extended release which releases drug slowly so that the plasma concentrations are maintained at a therapeutic level for a prolonged period of time (usually between 8 and 12 hours). Recent extended release formulationsRead MoreThe Human Gastrointestinal Track Is A Complex Time9513 Words   |  39 Pagesmetabolizing, and excretive organ. Key of physiological factors that control absorption of drugs from the GIT include gastric, fluid and food intake, bulk fluid and luminal pH, gastric and intestinal secretions, absorptive mechanisms, enterocyte-based metabolism and secretion. Properties of a drug, such as its solubility, stability, ionization, and lipophilicity, strongly influence the rate and extent of drug absorption from GI lumen. Critical assessment of fundamental physicochemical properties andRead MoreAntiepileptic Activity And Pharmacognostical Study Of Leaves Of Sphaeranthus Indicus Linn1087 Words   |  5 Pagespharmaceutical drugs are from natural products or either derivatives of natural products. The presently available AEDs (Antiepileptic drugs )i.e., phenobarbitone, benzodiazepine, sodium valproate and ethosuximide are associated with a number of s hort comings, dose related neurotoxicity and other side effects. Though AED therapy is meant for a long duration usage , because of this , there is a risk of drug interactions and this problem is further compounded by the high protein bindings for some drugs and potentialRead MoreHow Riluzole Is A Derivative Of Benzothiazole Essay724 Words   |  3 Pagesto slight yellow powder soluble in dimethylsulfoxide, dimethylformamide and methanol, freely soluble in dichloromethane, sparingly soluble in 0.1 N HCl and very slightly soluble in water and 0.1 N NaOH. Riluzole is available as a capsule-shaped, white, film-coated tablet for oral administration. Each tablet contains 50 mg of riluzole. It is marketed by Sanofi-Aventis with the brand name Rilutek. 2.11.3 Side-effects or damaging effects Riluzole is a very good neuroprotective drug, but it has someRead MorePowder X: Ray Diffraction1726 Words   |  7 PagesPowder X–Ray Diffraction Powder X–ray diffraction (PXRD) was used to provide an insight into the polymorphic nature of xylitols. The PXRD patterns of all xylitols were collected on a Bruker D8 Advance (Siemens, D5000, Germany) powder diffractometer with Cu KÃŽ ± radiation (1.54056 Ã…) using the DIFFRACplus software. Samples were placed into a stainless steel holder and the surface of each powder was levelled manually for analysis. Each sample was scanned from 2 to 40 of 2ÃŽ ¸ with a step size of 0.019 ºRead MoreDrug Profile : Drugs And Drugs1406 Words   |  6 PagesLevel 1: Drug Profile Coursework Drug substance: Pioglitazone Name: Cheong Hung Shing Student number: 40168923 Assessor: Dr P. McCague â€Æ' ï  ¬ 1.1 Source Pioglitazone is one kind of thiazolidinediones which is a type of anti-diabetic drugs. It is a synthetic substance. It has brand names of Actos ®. [1][2] ï  ¬ 1.2 Description Pioglitazone is 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. It has a chemical formula of C19H20N2O3S and a molecular weight of 356.4387 g/molRead MoreAcetate : A Synthetic Nonapeptide And Analogue Of Naturally Occurring Luteinizing Hormone Releasing Hormone1547 Words   |  7 Pages_ OOCCH,), has a very low octanol-water partition coefficient ( Adjei et al., 1989). Pharmacology and Clinical Use Leuprolide acetate is used in the treatment of prostate cancer, it is given subcutaneously and also a single dose per month intravenous administration (Adjei et al., 1989). Leuprolide has a poor oral bioavailability which is due to enzymatic degradation and its inability to permeate through the gut membrane. Due to limits of parenteral routes of drug administration, several researchesRead MoreRisperdal (Risperidone) Has Been Used For A Number Of Different1690 Words   |  7 Pages(Risperidone): Side Effects, Interactions, Warning, Dosage Uses, 2016). Risperdal Tablets are intended for oral administration. There are also other ways of administration available but we will be focusing mostly on the Risperdal Tablets with a few references to other administrations. Risperidone is a whitish powder which is insoluble in water, freely soluble in methylene chloride, and soluble in methanol. The inactive ingredients in Risperidone include colloidal silicon dioxide, hypromellose, lactose